長崎大学大学院医歯薬学総合研究科
発生分化機能再建学（形成外科）における私の研究変遷と現況

秋田 定伯　　
文　献
  1. Akita S, Webster J, Ren SG, Takino H, Said J, Zand O, Melmed S. Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J Clin Invest. 95(3):1288-1298, 1995.
  2. Akita S, Malkin J, Melmed S. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology. 137(7):3140-3143, 1996.
  3. Akita S, Conn PM, Melmed S. Leukemia inhibitory factor (LIF) induces acute adrenocorticotrophic hormone (ACTH) secretion in fetal rhesus macaque primates: a novel dynamic test of pituitary function. J Clin Endocrinol Metab. 81(11):4170-4178, 1996.
  4. Akita S, Readhead C, Stefaneanu L, Fine J, Tampanaru-Sarmesiu A, Kovacs K, Melmed S. Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts. J Clin Invest. 99:2462-2469, 1997.
  5. Rashid MA, Akita S, Razzaque MS, Yoshimoto H, Ishihara H, Fujii T, Tanaka K, Taguchi T. Coadministration of basic fibroblast growth factor and sucrose octasulfate (sucralfate) facilitates the rat dorsal flap survival and viability. Plast Reconstr Surg. 103:941-948, 1999.
  6. Akita S, Ishihara H, Rashid MA, Fujii T. Leukemia inhibitory factor (LIF) gene improves skin allograft survival in the mouse model. Transplantation. 70: 1026-1031,2000.
  7. Dazai S, Akita S, Hirano A, Rashid MA, Naito S, Akjno K, Fujii T. Leukemia inhibitory factor enhances bone formation in calvarial bone defect. J Craniofac Surg. 11:513-520, 2000.
  8. Akita S, Rashid MA, Ishihara H, Daian T, Dazai S, Fujii T. Cytokine-dependent gp130 receptor subunit regulates rat modified axial-pattern epigastric flap. J Invest Sug. 15:137-151, 2002
  9. Akino K, Mineta T, Fukui M, Fujii T, Akita S. Bone morphogenetic protein-2 regulates proliferation of human mesenchymal stem cells. Wound Rep Reg. 11: 354-360, 2003
  10. Akita S, Nakagawa H, Akino K, Fukui M, Fujii T. Cellules souches pour la cicatrisation des plaies cutanees Journal des Plaies et Cicatrisations 8: 13-17, 2003
  11. Akita S, Fukui M, Nakagawa H, Fujii T, Akino K. Cranial bone defect healing is accelerated by mesenchymal stem cell by co-administration of bone morphogenetic protein-2 and basic fibroblast growth factor. Wound Repair Regen. 12: 254-261, 2004
  12. Akita S, Daian T, Ishihara H, Fujii T, Akino K. Leukemia inhibitory factor-transfected embryonic fibroblasts and vascular endothelial growth factor successfully improve the skin substitute wound healing by increasing angiogenesis and matrix production. J Dermatol Sci 36: 11-23, 2004
  13. Nakagawa H, Akita S, Fukui M, Fujii T, Akino K. Human mesenchymal stem cells successfully improve skin-substitute wound healing. Brit J Dermatol, in press
  14. Akino K, Mineda T, Akita S. Early cellular changes of human mesenchymal stem cells and their interaction with other cell types. Wound Repair Regen, in press.
  15. Fukui M, Akita S, Akino K. Ectopic bone formation facilitated by human mesenchymal stem cells and osteogenic cytokines via nutrient vessel injection in a nude rat model. Wound Repair Regen, in press.

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